
- Made by
- Testes (men); ovaries and adrenals (women)
- Best time to test
- Morning, roughly 7 to 10 a.m.
- Forms measured
- Total, free and bioavailable
- Low-T cutoff (AUA)
- Total testosterone below 300 ng/dL
What testosterone does
- Sexual desire and erectile function.
- Muscle mass and strength, and fat distribution.
- Bone density.
- Red blood cell production.
- Sperm production, along with FSH.
- Energy and mood, though these are influenced by many other factors.
How it is controlled
The brain controls testosterone production. The pituitary releases LH, which tells the testes to make testosterone, and rising testosterone tells the brain to ease off. That loop is why testosterone therapy from outside the body lowers LH, sperm production and testicle size in many men.
How it is measured
Most testosterone in blood is attached to SHBG or albumin. A total testosterone test counts all of it and is the standard starting point. Free and bioavailable tests estimate the active portion and are useful when SHBG is abnormal. Because levels peak in the morning, MedlinePlus notes samples are usually drawn between 7 and 10 a.m.
Results must be read with symptoms and age. Acute illness, poor sleep, opioids and heavy alcohol use can all temporarily lower readings.
Low testosterone in men
Both the American Urological Association and the Endocrine Society require symptoms plus consistently low morning results on separate days before diagnosing deficiency. The Endocrine Society advises against screening men without symptoms. A gradual, age-related dip without symptoms is not, by itself, a reason to treat.
Treatment requires monitoring of hematocrit, PSA in men over 40, and testosterone levels. It suppresses sperm production, so it is not suitable for men trying to conceive.
Testosterone in women
Women make far less testosterone, and levels decline gradually with age. MedlinePlus notes testing in women is mostly done to investigate signs of excess, such as unwanted hair growth or irregular periods, which can point to PCOS or adrenal conditions. Testosterone treatment for women is an evolving area with limited approved options, and any use requires careful monitoring.
At HealifyMD
Testosterone Replacement Therapy through HealifyMD is $249 for the first month and $149/month after, confirmed at your eligibility review. The first month includes the lab panel. A licensed clinician confirms the diagnosis with morning labs, reviews risks including higher hematocrit and fertility suppression, and sets a monitoring schedule.
Common myths
Testosterone is often marketed as a fix for every midlife complaint, from fatigue to weight gain. In reality, those symptoms have many causes, including sleep apnea, depression, thyroid disease and medication side effects. Testing confirms whether testosterone is actually part of the picture, and treatment is meant to correct a deficiency rather than push levels as high as possible.
Testosterone: common questions
At what age does testosterone start declining?
Levels generally peak in early adulthood and decline gradually afterward, but the rate varies widely between individuals.
Can lifestyle raise testosterone?
Weight loss, sleep, regular exercise and reducing alcohol can help in some men, particularly when obesity or poor sleep is a factor.
Does testosterone therapy cause infertility?
It often lowers sperm production, sometimes to zero. Men who want children should discuss alternatives before starting.
Why is my testosterone low in the afternoon?
Testosterone follows a daily rhythm and is highest in the morning, so afternoon results can look misleadingly low.
Is testosterone safe for the heart?
Research on heart effects has been mixed, and recent heart attack or stroke is a reason not to start. Your clinician weighs your personal risk factors before prescribing.
Can women be prescribed testosterone?
Sometimes, for specific situations such as low sexual desire after menopause, but approved products for women are limited in the U.S. and monitoring is essential.
Sources
We cite government agencies, professional societies and peer-reviewed research. See our editorial policy.
- Testosterone levels testMedlinePlus (U.S. National Library of Medicine)
- Evaluation and Management of Testosterone Deficiency guidelineAmerican Urological Association
- Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline (2018)Endocrine Society
- Hematocrit testMedlinePlus (U.S. National Library of Medicine)